Motif ID: SOX{8,9,10}.p2

Z-value: 1.687


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_367104840.401.2e-01Click!
SOX9chr17_+_676287630.263.3e-01Click!
SOX8chr16_+_9718080.068.4e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_128883125 4.860 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr2_+_101680594 3.051 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr7_-_27171673 2.429 NM_152739
HOXA9
homeobox A9
chr12_-_6103945 2.407 NM_000552
VWF
von Willebrand factor
chr3_+_195336625 2.369 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr7_-_27171648 2.337 HOXA9
homeobox A9
chr7_-_27171600 2.332 HOXA9
homeobox A9
chr6_-_11340869 2.268 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11340886 2.213 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11340887 2.197 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_-_187309442 2.016 NM_004454
ETV5
ets variant 5
chr4_-_7991992 2.008 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr5_-_16989371 1.985 NM_012334
MYO10
myosin X
chr9_+_123501186 1.970 DAB2IP
DAB2 interacting protein
chr6_+_148705421 1.957 NM_015278
SASH1
SAM and SH3 domain containing 1
chr5_-_16989290 1.929 MYO10
myosin X
chr17_-_76985538 1.844


chr1_-_95165037 1.800 CNN3
calponin 3, acidic
chr3_-_189354510 1.793 LOC339929
hypothetical LOC339929
chr21_+_17807167 1.762 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr1_-_151848039 1.728 S100A16
S100 calcium binding protein A16
chr10_+_73393998 1.721 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr3_-_150422474 1.703 NM_000096
CP
ceruloplasmin (ferroxidase)
chrX_+_15428820 1.655 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr10_-_97311084 1.647 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr17_-_37196463 1.627 NM_002230
NM_021991
JUP

junction plakoglobin

chr7_-_5429702 1.624 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr9_+_115303527 1.614 NM_130795
RGS3
regulator of G-protein signaling 3
chr11_+_101488380 1.560 NM_001195045
YAP1
Yes-associated protein 1
chr1_+_15957832 1.557 NM_017556
FBLIM1
filamin binding LIM protein 1
chr3_+_189354167 1.540 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_+_85066265 1.538 FLRT2
fibronectin leucine rich transmembrane protein 2
chr10_+_104525877 1.528 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_-_94475504 1.522 ARHGAP29
Rho GTPase activating protein 29
chr3_+_195336631 1.499 HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_62740878 1.497 NM_020663
RHOJ
ras homolog gene family, member J
chr16_+_81218142 1.474 CDH13
cadherin 13, H-cadherin (heart)
chr14_-_37795290 1.468 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr6_+_114285209 1.467 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr8_+_40130143 1.465 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr11_+_129496792 1.449 APLP2
amyloid beta (A4) precursor-like protein 2
chr7_-_27186400 1.402 NM_153715
HOXA10
homeobox A10
chr1_-_223907283 1.386 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr5_+_40715778 1.363 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr1_-_85703198 1.354 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr5_+_40715799 1.340 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr16_+_81218074 1.339 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr1_+_207668787 1.338 NM_001104548
LOC642587
NPC-A-5
chr14_+_85066207 1.332 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr8_-_119192985 1.329 NM_000127
EXT1
exostosin 1
chr7_+_77005287 1.282 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr20_+_29656744 1.281 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr14_-_37795001 1.279 CLEC14A
C-type lectin domain family 14, member A
chr2_-_164300758 1.259 NM_018086
FIGN
fidgetin
chr11_+_20005704 1.256 NAV2
neuron navigator 2
chr15_+_37660568 1.255 NM_003246
THBS1
thrombospondin 1
chr2_-_239987557 1.254 NM_006037
HDAC4
histone deacetylase 4
chr1_-_12599934 1.250 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_-_95165089 1.249 NM_001839
CNN3
calponin 3, acidic
chr12_+_62524778 1.243 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr3_-_150533948 1.231 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr2_-_151052391 1.215 NM_005168
RND3
Rho family GTPase 3
chr1_-_177378801 1.193 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr11_-_27450808 1.191 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr6_-_72187168 1.190 C6orf155
chromosome 6 open reading frame 155
chr1_-_197173159 1.185 LOC100131234
familial acute myelogenous leukemia related factor
chr8_+_55533047 1.175 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr7_-_11838260 1.164 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr12_-_57600564 1.141 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_+_93686154 1.131 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr17_+_72795567 1.123 NM_001113492
SEPT9
septin 9
chr4_-_186969041 1.120 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr14_+_23008723 1.119 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr1_+_43539239 1.117 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr18_+_3441589 1.112 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr3_+_43303005 1.106 NM_001100594
NM_017719
SNRK

SNF related kinase

chr16_-_21344158 1.105 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr15_-_53822468 1.102 NM_173814
PRTG
protogenin
chr15_-_68781662 1.082 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_-_204108151 1.073 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr16_+_64958025 1.070 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr16_+_64958060 1.069 CDH5
cadherin 5, type 2 (vascular endothelium)
chr2_-_56266408 1.052 LOC100129434
hypothetical LOC100129434
chr1_-_79244948 1.048 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr7_-_107430566 1.047 NM_002291
LAMB1
laminin, beta 1
chr2_-_128138435 1.045 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr5_-_125958503 1.043 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr18_+_7936885 1.041 PTPRM
protein tyrosine phosphatase, receptor type, M
chr2_+_54536780 1.041 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr12_-_94135154 1.034 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr7_-_111633428 1.028 DOCK4
dedicator of cytokinesis 4
chr10_-_105835525 1.020 COL17A1
collagen, type XVII, alpha 1
chr10_-_105835609 1.016 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr3_-_150993299 1.016 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr16_-_73842884 1.002 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr9_+_80101810 0.999 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr7_+_134114957 0.995 CALD1
caldesmon 1
chr17_-_71017509 0.987 NM_001142643
CASKIN2
CASK interacting protein 2
chr7_+_134114912 0.985 CALD1
caldesmon 1
chr3_-_150578023 0.973 TM4SF1
transmembrane 4 L six family member 1
chr12_-_69289889 0.972 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr9_-_73573121 0.966 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr14_+_23008742 0.956 NGDN
neuroguidin, EIF4E binding protein
chr12_-_87498225 0.950 NM_000899
NM_003994
KITLG

KIT ligand

chr16_+_64958086 0.942 CDH5
cadherin 5, type 2 (vascular endothelium)
chr2_+_152900076 0.939 FMNL2
formin-like 2
chr10_-_123346148 0.934 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr2_-_239987629 0.929 HDAC4
histone deacetylase 4
chr3_-_48445719 0.926 NM_002673
PLXNB1
plexin B1
chr17_-_38979178 0.912 NM_001079675
ETV4
ets variant 4
chr16_+_22432344 0.911 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr3_-_101077605 0.908 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr9_+_96807107 0.904 C9orf3
chromosome 9 open reading frame 3
chr4_+_74491272 0.903 ALB
albumin
chr19_+_60543032 0.897 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr1_-_68470585 0.889 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_+_167342149 0.883 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr16_-_52877829 0.879 IRX3
iroquois homeobox 3
chr9_+_27099138 0.879 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr3_+_138020550 0.872 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr11_-_128567302 0.868 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr12_-_51173238 0.867 NM_005554
KRT6A
keratin 6A
chr12_+_94135645 0.865 NM_017599
VEZT
vezatin, adherens junctions transmembrane protein
chr2_-_70329067 0.846 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr12_-_57600336 0.845 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr20_-_55718982 0.842 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr18_+_3439972 0.840 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr2_+_37425240 0.837 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr20_-_13567529 0.833 NM_017714
TASP1
taspase, threonine aspartase, 1
chr6_-_2785682 0.832 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr5_+_149960820 0.832 NM_001166208
SYNPO
synaptopodin
chrX_+_67965517 0.827 NM_004429
EFNB1
ephrin-B1
chr4_-_89963177 0.819 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr19_+_50663089 0.805 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr5_-_92942680 0.804 FLJ42709
hypothetical LOC441094
chr7_+_12693729 0.798 ARL4A
ADP-ribosylation factor-like 4A
chr12_+_52665196 0.793 NM_017409
HOXC10
homeobox C10
chr12_-_106011715 0.790 NM_004075
CRY1
cryptochrome 1 (photolyase-like)
chr1_+_67923660 0.789 GADD45A
growth arrest and DNA-damage-inducible, alpha
chrX_-_44945025 0.785 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr10_-_105982052 0.779 NM_025145
WDR96
WD repeat domain 96
chr1_+_67923331 0.777 NM_001924
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr8_+_21980315 0.775 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr15_-_39973566 0.771 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr1_+_176577228 0.760 NM_004841
RASAL2
RAS protein activator like 2
chr17_-_59817456 0.760 PECAM1
platelet/endothelial cell adhesion molecule
chr10_+_24795465 0.759 KIAA1217
KIAA1217
chr1_-_94475840 0.757 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr10_+_24795446 0.756 KIAA1217
KIAA1217
chr9_-_74757735 0.755 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_-_50714836 0.753 LOC642366
hypothetical LOC642366
chr17_+_75366524 0.748 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr15_+_68971835 0.748 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr3_+_190990142 0.747 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr6_-_10523424 0.740 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_-_59818033 0.735 PECAM1
platelet/endothelial cell adhesion molecule
chr2_+_160180092 0.732 LOC643072
hypothetical LOC643072
chr14_+_22375753 0.731 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr9_-_35101534 0.731 KIAA1539
KIAA1539
chr12_-_108802561 0.724 NM_016433
GLTP
glycolipid transfer protein
chr6_+_30702586 0.724 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr7_+_116099648 0.723 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr6_+_43565192 0.720 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr1_+_144439069 0.720 NM_002614
PDZK1
PDZ domain containing 1
chr1_-_167721723 0.716 NM_006996
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr16_+_27468942 0.715 NM_015202
KIAA0556
KIAA0556
chrX_+_70359780 0.714 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr1_+_85819004 0.713 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_-_33585848 0.708


chr16_-_52877868 0.703 NM_024336
IRX3
iroquois homeobox 3
chr11_-_88864061 0.700 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr18_+_18003401 0.699 NM_005257
GATA6
GATA binding protein 6
chr4_-_159312973 0.698 FAM198B
family with sequence similarity 198, member B
chr4_-_101658094 0.690 NM_001159694
NM_016242
EMCN

endomucin

chr17_-_59817654 0.685 PECAM1
platelet/endothelial cell adhesion molecule
chr10_-_33287184 0.683 NM_002211
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr1_-_6468600 0.681 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr9_-_35101592 0.675 KIAA1539
KIAA1539
chr13_-_40138607 0.673 NM_002015
FOXO1
forkhead box O1
chr5_+_50714996 0.668 ISL1
ISL LIM homeobox 1
chr6_-_29752909 0.668 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr16_+_464844 0.666 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr4_-_110942576 0.665 CFI
complement factor I
chr2_+_62786290 0.662 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr7_+_16652282 0.656 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2

chr4_-_110942783 0.655 NM_000204
CFI
complement factor I
chr16_-_30705707 0.654 NM_001080417
ZNF629
zinc finger protein 629
chr7_+_12693435 0.653 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr6_-_80303822 0.652 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr18_+_54039818 0.652 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_-_106846253 0.647 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr20_-_17459973 0.645 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr17_-_59817575 0.644 PECAM1
platelet/endothelial cell adhesion molecule
chr5_+_148186348 0.644 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr4_-_186969202 0.640 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr4_-_159313167 0.640 NM_016613
FAM198B
family with sequence similarity 198, member B
chr2_+_159021653 0.638 PKP4
plakophilin 4
chr14_-_54948290 0.636 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chr12_-_10142779 0.635 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr12_+_51730101 0.634 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 2.14e-08 GO:0032502 developmental process
1.36 3.14e-08 GO:0007275 multicellular organismal development
2.11 6.75e-06 GO:0007264 small GTPase mediated signal transduction
1.32 2.19e-05 GO:0048856 anatomical structure development
1.34 5.56e-05 GO:0048731 system development
1.46 5.39e-04 GO:0007399 nervous system development
1.20 1.31e-03 GO:0032501 multicellular organismal process
1.87 1.64e-03 GO:0007409 axonogenesis
1.99 1.79e-03 GO:0007411 axon guidance
1.35 2.77e-03 GO:0048869 cellular developmental process
1.26 2.79e-03 GO:0016043 cellular component organization
1.68 3.98e-03 GO:0032989 cellular component morphogenesis
1.76 4.29e-03 GO:0000904 cell morphogenesis involved in differentiation
1.34 5.23e-03 GO:0030154 cell differentiation
1.80 5.29e-03 GO:0048812 neuron projection morphogenesis
2.01 5.49e-03 GO:0030029 actin filament-based process
1.81 5.87e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
2.09 6.21e-03 GO:0030036 actin cytoskeleton organization
1.24 9.52e-03 GO:0071840 cellular component organization or biogenesis
1.54 1.14e-02 GO:0040011 locomotion
1.64 1.86e-02 GO:0000902 cell morphogenesis
1.14 2.13e-02 GO:0050789 regulation of biological process
1.27 2.91e-02 GO:0071842 cellular component organization at cellular level
1.69 3.01e-02 GO:0032990 cell part morphogenesis
1.37 3.62e-02 GO:0009653 anatomical structure morphogenesis
1.13 4.11e-02 GO:0065007 biological regulation
1.68 4.20e-02 GO:0048858 cell projection morphogenesis
1.08 4.21e-02 GO:0009987 cellular process
5.26 4.31e-02 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.85 1.20e-06 GO:0030054 cell junction
2.69 2.29e-06 GO:0070161 anchoring junction
2.68 1.45e-05 GO:0005912 adherens junction
2.92 2.03e-04 GO:0005925 focal adhesion
2.78 3.57e-04 GO:0030055 cell-substrate junction
1.09 4.06e-04 GO:0005622 intracellular
2.13 5.45e-04 GO:0016323 basolateral plasma membrane
2.78 5.67e-04 GO:0005924 cell-substrate adherens junction
1.13 6.23e-04 GO:0005737 cytoplasm
1.39 8.86e-04 GO:0005856 cytoskeleton
1.08 2.56e-03 GO:0044424 intracellular part
2.03 1.52e-02 GO:0005911 cell-cell junction
1.82 1.86e-02 GO:0015629 actin cytoskeleton
7.93 4.73e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 3.99e-04 GO:0005515 protein binding
1.08 1.93e-03 GO:0005488 binding
2.01 3.52e-03 GO:0005096 GTPase activator activity
1.63 4.68e-02 GO:0030695 GTPase regulator activity